The retail sector is experiencing unprecedented change, from ongoing shifts in shopping behaviour to retailer rationalisation and business failure. Internationally, this is impacting the crucial economic and social role of many highly developed city centres. This paper examines how key stakeholders have responded to the challenges of adapting city centres for the future. Empirically, the paper draws on a series of repurposing schemes across five case study cities. Conceptually, theories of assemblage are used as an analytical framework to understand how heterogeneous networks combine to repurpose city centres. The paper makes a distinctive contribution by revealing symbiosis between mixed uses that challenge traditional high street norms, and suggests that harnessing common desires could underpin productive shared governance and support business communities' efforts to bring vibrancy and enhance resilience.