This paper explores physicians’ responses to the suicide of a female surgeon colleague in order to detail the cultural patterning of the problem of suicide within biomedicine. More broadly, it argues that suicide provides an exemplary case of reckoning with uncertainty. Data sources include 124 hours of person-centered and semistructured interviews with 65 individuals, including 54 physicians, 28 of whom are female surgeons. I argue that the cultural model of suicide articulated by physicians reflects an ultimately ineffective strategy for managing suicide’s multisource uncertainty, with the suicide of a colleague exposing the moral and affective entailments of a limit case of prognostication. Examining patterns in physician responses to suicide, I define “bewilderment” as a state of having no means of getting to know, and I detail the ways in which physicians’ aversive reaction to bewilderment undermine knowledge acquisition. I describe suicide’s distinct challenges to biomedicine’s social power, including suicide’s contestation of narratives about the future. Finally, I raise questions about the degree to which biomedical framings of suicide may undermine the ability of biomedical actors to develop effective interventions to address it. Exploring responses to suicide as a form of cultural production can illustrate fundamental tensions about uncertainty and causality.